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Dosage should be reduced Per the elderly or debilitated because these patients may be more sensitive to barbiturates. Dosage should be reduced for patients with impaired renal function or hepatic disease.
Reports of infants suffering from long-term barbiturate exposure Con utero included the acute withdrawal syndrome of seizures and hyperirritability from birth to a delayed onset of up to 14 days. (See “Drug Abuse And Dependence” section.)
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